CORAFAX-500

COMPOSITION: - CEFUROXIME 500MG

PACKING: - 10X1X6

M.R.P: - 3600

CEFUROXIME 500 MG: - Cefuroxime is an antibiotic which is active against wide range of gram positive and gram negative bacteria. It is a cephalosporin antibiotic. It acts by inhibiting the bacterial cell wall growth.

PHARMACODYNAMICS: - Cefuroxime is a second-generation cephalosporin, this works as penicillin. It interrupts the synthesis of bacterial cell wall by interfering the formation of major components essential for the formation of cell wall i.e. peptidoglycan. Like penicillins, Cefuroxime binds to penicillin binding proteins in the bacterial cell wall which affects the synthesis of bacterial cell wall. Ultimately, Cell lysis is initiated with autolytic enzymes in the cell wall such as autolysins.

PHARMACOKINETICS:-

• ABSORPTION: - The absorption takes place from the GIT. It is observed that absorption is greater in the presence of food.
• PROTEIN BINDING: - About half of the drug concentration binds to serum protein.
• METABOLISM: - The metabolised components are acetaldehyde and acetic acid.
• HALF-LIFE: - On intramuscular or intravenous injection 80 minutes of Half-Life is observed.

INDICATIONS: - It treats different types of bacterial infections like: -

• Urinary Tract Infections
• Tonsillitis
• Gonorrhoea
• Ear infections
• Bronchitis