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Arteether is a fast acting blood schuzonticidal agent for Plasmodium falciparum malaria at the erythrocytic stage.
Indications • Severe Malaria including Cerebral Malaria
• And in Second line drug in chloroquine resistant malaria
The functional group responsible for antimalarial activity of a / ß Arteether is endoperoxide bridge. Iron from the digested haemoglobin of the parasite victim reduces this brighe releasing a highly reactive free radical iron species which causes clearance of parasitic cells.
• Gastro-Intenstinal tract activity