Arteether is a fast acting blood schuzonticidal agent for Plasmodium falciparum malaria at the erythrocytic stage. Indications • Severe Malaria including Cerebral Malaria • And in Second line drug in chloroquine resistant malaria Pharmacodynamics The functional group responsible for antimalarial activity of a / ß Arteether is endoperoxide bridge. Iron from the digested haemoglobin of the parasite victim reduces this brighe releasing a highly reactive free radical iron species which causes clearance of parasitic cells. Side Effects • Nausea • Dizziness • Depression • Gastro-Intenstinal tract activity