Arlak Biotech Pvt.Ltd.
Arlak Biotech Pvt.Ltd. SCO 1,Wadhwa Nagar, Near Hotel Sun park,Kalka Highway , Zirakpur , Punjab , ( 140603 ) India
Product Details:
Product Type: Injection
Brand Name: Arlak Biotech
Packaging Type VIAL
Packaging: 1.5 gm
Composition / Material Type: Cefoperazole & sulbactam injection
Usages: Inject
Get Latest Price

SIGBECT-S 1.5 GM INJECTION

COMPOSITION: - CEFOPERAZONE 1000 MG & SULBACTUM 500 MG

PACKING: - Vial

M.R.P: - 189

Pharmacology

Cefoperazone

Pharmacodynamics:- Cefoperazone is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefoperazone inhibits Transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporin’s like Cefoperazone. It has greater action against pseudomonas & has good action against salmonella typhi & B.fragilis.

Pharmacokinetics

  • Absorption: Orally not well absorbed & should be given parenterally,
  • Distribution: widely distributed & good CSF penetration,
  • Metabolism: It is not significantly metabolized inside the body.
  • Excretion: Excreted mainly through bile & a small portion is excreted in urine. A small amount is seen in breast milk.

Sulbactum

Pharmacodynamics: – Sulbactam has no significant antimicrobial activity, despite sharing the?-lactam ring that is characteristic of beta-lactam antibiotics. This similarity in chemical structure helps the Sulbactam to act as a competitive inhibitor of beta-lactamase enzyme secreted by certain bacteria that are resistant to beta-lactam antibiotics. This inhibition restores the antibacterial activity of beta-lactam antibiotics against Beta-lactamase-secreting resistant bacteria. It is usually given in combination with Amoxycillin. It is used to increase the antibacterial spectrum of penicillin and cephalosporin against penicillinase-producing and beta-lactamase-producing organisms such as Staphylococcus aureus, H. flu, Moraxella catarrhalis that are resistant to Ampicillin alone.

INDICATIONS Cefoperazone Meningitis Biliary infections Septicemia Infections in immune compromised patients Urinary tract &genital tract infections Surgical prophylaxis Skin & soft tissue infections Bone & Joint infections Gonorrhea Sulbactam Skin infections Intra abdominal infections Gynecologic infections.

Click more